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High Resolution TOFMS

LECO’s most recent innovation in the gas chromatography sector, the Pegasus GC-HRT+ 4D, provides users with the unprecedented ability to investigate complex samples and identify unknown analytes. Combining the highest performance GCxGC and TOFMS on the market with High Resolution Deconvolution® (HRD®), users are able to find more analytes than ever before and identify components with ultimate confidence.

These advances in technology are paired with LECO’s ChromaTOF® brand software, which is tailored to get the most out of your High Resolution data when used in conjunction with NIST and Accurate Mass Libraries. Further features such as the generation of Pseudo-Molecular ions via Chemical Ionization, retention time matching, isotope patterns, and mass accuracy of deconvoluted fragments, all lead to confident identification.

With mass accuracies of 1 ppm and peak capacity potential at least two times greater than any mass spectrometer currently available on the marketplace, the Pegasus GC-HRT+ 4D is the solution to winning the fight against coelution and analyzing even the most complex samples.

 

Click here to visit our ASMS Video Gallery featuring presentations by actual users.

Pegasus GC-HRT+ 4D Brochure

GC-TOFMS Technology Overview Brochure

 

For real-world application information using our products, please check out our e-seminar video gallery and technical presentations.

Description

  • The Pegasus GC-HRT+ 4D combines the highest-performance GC×GC and Time-of-Flight Mass Spectrometry (TOFMS) technologies with High Resolution Deconvolution (HRD). Designed for the analysis of the most complex samples, the system enables users to find more analytes than ever before and confidently identify unknown components.

    The instrument is powered by ChromaTOF® software, specifically designed for HRT+ instrumentation and GC×GC applications. The software provides advanced qualitative and quantitative capabilities in a single, user-friendly data system.

    The Pegasus GC-HRT+ 4D delivers high-resolution mass spectral data using comprehensive two-dimensional gas chromatography (GC×GC). In this process, compounds eluting from the first chromatographic column are trapped and systematically injected into a second column to achieve a second chromatographic separation. This second separation is completed within seconds, producing very narrow chromatographic peaks of less than 200 milliseconds.

    To accurately define a two-dimensional chromatographic peak, acquisition rates of at least 100 spectra per second are required. The Pegasus GC-HRT+ 4D supports acquisition rates of up to 200 spectra per second, providing sufficient data density for spectral deconvolution of chromatographic peaks. Combined, LECO’s GC×GC chromatography and the Pegasus GC-HRT+ 4D provide a solution for complex sample characterization.


    Key Features

    • High-performance GC×GC and TOFMS combined with High Resolution Deconvolution (HRD)
    • Designed for the analysis of highly complex samples
    • Enables detection of more analytes and confident identification of unknown components
    • ChromaTOF® software designed for HRT+ instrumentation and GC×GC applications
    • Advanced qualitative and quantitative capabilities
    • Sleek benchtop design to save valuable laboratory space
    • Industry-leading sensitivity for analyte detection and quantification
    • Proprietary deconvolution algorithms for clean, high-quality spectra
    • Complete historical record of mass spectral components retained for future data mining
    • Proven Pegasus reliability and durability in a convenient benchtop unit
    • High-resolution mass spectral data using comprehensive two-dimensional gas chromatography (GC×GC)
    • Chromatographic peak widths of <200 milliseconds
    • Data acquisition rates up to 200 spectra per second

    Working Principle

    The Pegasus GC-HRT+ 4D utilizes comprehensive two-dimensional gas chromatography (GC×GC) to increase chromatographic peak capacity. Compounds eluting from the first chromatographic column are trapped and systematically injected into a second chromatographic column, where a second separation is performed.

    The second chromatographic separation is completed within seconds, producing narrow chromatographic peaks that require high-speed spectral acquisition for accurate characterization. With acquisition rates of up to 200 spectra per second, the instrument provides sufficient data density for spectral deconvolution of chromatographic peaks.


    Available Models

    Model Description
    Pegasus GC-HRT+ 4D With Liquid Nitrogen Thermal Modulator
    Pegasus GC-HRT+ 4D With Cryogen-Free Modulator

    Options

    • L-PAL3 Autosampler

    Software

    ChromaTOF® Software

    Designed specifically for HRT+ instrumentation and GC×GC support, ChromaTOF® software provides:

    • Advanced qualitative analysis
    • Advanced quantitative analysis
    • User-friendly all-in-one data system

    Featured Applications

    • Modern-day Urinalysis: Combining Enhanced Chromatography with High Resolution Time-of-Flight Mass Spectrometry to Discover Potential Prostate Cancer Biomarkers in Human Urine
    • Characterization of PFAS and Other Pollutants in Household Dust Using GC×GC-HRTOFMS and Spectral Analysis Tools (SAT)
    • Polychlorinated Paraffins (PCP) Analysis
    • Distinguishing Analytes in Perfume
    • GC×GC-HRT Aroma Analysis of Perfume Samples

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